Two drifters, George and his friend Lennie, have just arrived at a ranch, to work for enough money to buy their own place. Lennie is a man-child, a little boy in the body of a dangerously powerful man. It's Lennie's obsessions with things soft and cuddly, that have made George cautious about with whom the gentle giant associates with. His promise to allow Lennie to "tend to the rabbits" on their future land keeps Lennie calm, amidst distractions, as the overgrown child needs constant reassurance. But when a ranch boss' promiscuous wife is found dead in the barn with a broken neck, it's obvious that Lennie, albeit accidentally, killed her. George, now worried about his own safety, knows exactly where Lennie has gone to hide, and he meets him there. Realizing they can't run away anymore, George is faced with a moral question: how should he deal with Lennie before the ranchers find him and take matters into their own hands.